inactivated vaccines

Dengue vaccine development has been in progress for more than 60 years, despite all these efforts, there is still a lack of an efficacious and safe vaccine for dengue. The development of an effective vaccine against Dengue has been a real challenge. There are several dengue vaccine development strategies that include live attenuated vaccines, chimeric, DNA-based, subunit, and inactivated vaccines. Propose novel approaches or strategies in developing the next generation dengue virus vaccine and how your approach or strategies can overcome the current challenges in dengue virus vaccine development